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Don Mariano Marcos Memorial State University (DMMMSU [ˈdimsʊ]; Filipino: Pang-alaalang Pamantasang Pampamahalaang Don Mariano Marcos) is the state university system serving the province of La Union in the Philippines. Its main autonomous unit is in Bacnotan. It was created by 10th president Ferdinand Marcos by using Presidential Decree 1778 to combine a number of state-run schools in La Union into a single state college in 1981. Like Mariano Marcos State University in Ilocos Norte, it is named for the former president's father, Mariano Marcos.

Before 1993, DMMMSU occupied seven campuses throughout the province. After a reorganization that year, these campuses were grouped into four autonomous units, simply called the North La Union Main Campus (DMMMSU-NLUC), the Mid La Union Campus (DMMMSU-MLUC), the South La Union Campus (DMMMSU-SLUC), and the Open University System (DMMMSU-OU). Each unit is headed by a chancellor/director, while the whole system is headed by the university president Dr. Jaime I. Manuel Jr.