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Medellín ( MED-ə-LEEN MED-ay-(Y)EEN; Spanish: [meðeˈʝin] or [meðeˈʎin]), officially the Special District of Science, Technology and Innovation of Medellín (Spanish: Distrito Especial de Ciencia, Tecnología e Innovación de Medellín), is the second-largest city in Colombia after Bogotá, and the capital of the department of Antioquia. It is located in the Aburrá Valley, a central region of the Andes Mountains, in northwestern South America. The city's population was 2,508,452 at the 2018 census. The metro area of Medellín is the second-largest urban agglomeration in Colombia in terms of population and economy, with more than 4 million people.

In 1616, the Spaniard Francisco de Herrera Campuzano erected a small indigenous village (poblado) known as "Saint Lawrence of Aburrá" (San Lorenzo de Aburrá), located in the present-day El Poblado commune. On 2 November 1675, the queen consort Mariana of Austria founded the "Town of Our Lady of Candelaria of Medellín" (Villa de Nuestra Señora de la Candelaria de Medellín) in the Aná region, which today corresponds to the center of the city (east-central zone) and first describes the region as "Medellín". In 1826, the city was named the capital of the Department of Antioquia by the National Congress of the nascent Republic of Gran Colombia, comprising present-day Colombia, Venezuela, Ecuador, and Panama. After Colombia won its independence from Spain, Medellín became the capital of the Federal State of Antioquia until 1888, with the proclamation of the Colombian Constitution of 1886. During the 19th century, Medellín was a dynamic commercial center, first exporting gold, then producing and exporting coffee.

Towards the end of the 20th century and into the beginning of the 21st, the city regained industrial dynamism, with the construction of the Medellín Metro commuter rail, liberalized development policies and improvement in security and education. Researchers at the Overseas Development Institute have lauded the city as a pioneer of a post-Washington Consensus "local development state" model of economic development. The city is promoted internationally as a tourist destination and is considered a global city type "Gamma +" by the Globalization and World Cities Research Network. The Medellín Metropolitan Area produces 67% of the Department of Antioquia's GDP and 11% of the economy of Colombia. Medellín is important to the region for its universities, academies, commerce, industry, science, health services, flower-growing, and festivals.

In February 2013, the Urban Land Institute chose Medellín as the most innovative city in the world due to its recent advances in politics, education, and social development. In the same year, Medellín won the Veronica Rudge Urbanism Award conferred by Harvard University to the Urban Development Enterprise, mainly due to the North-Western Integral Development Project in the city. Medellín hosted UN-Habitat's 7th World Urban Forum in 2014. In 2016, the city won the Lee Kuan Yew World City Prize. The award seeks to recognize and celebrate efforts in furthering innovation in urban solutions and sustainable urban development.