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Santa Fe is a district (distrito) of Veraguas Province in Panama. The population according to the 2000 census was 12,890; the latest official estimate (for 2019) is 17,341. The district, which lies in the north of the province and comprises its entire Caribbean coastal area, covers a total area of 1,920 km². The capital lies at the town of Santa Fe.

Santa Fe is known throughout Panamá for its orchids. There is an orchid exposition every August. Santa Fe is also known for being rich in wildlife. The diversity of plants and animals in El Parque Nacional de Santa Fe is especially impressive.

The Artisan Market in the Cabecera de Santa Fe makes and sells classic Panamá hats that are more durable and cheaper than hats found elsewhere in Panamá. In addition to the hats the artisan market also sells handmade indigenous style dresses for women and girls, as well as traditional hand-woven bags called "chakaras". The dresses and chakaras are characterized by bright colors and geometric patterns.